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In conclusion, the integration of advanced radiation therapy techniques, precise treatment planning, and individualized dose fractionation schemes is paramount in minimizing brain exposure and protecting brain health while achieving optimal therapeutic outcomes

Furthermore, we discuss the potential of antioxidant-based strategies and propose future directions for targeted therapies

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14 The incidence of rash has been reported in 11% of patients treated with nivolumab and pembrolizumab and 19% of those treated with ipilimumab in clinical trials

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