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However, efficacy is variable, adverse effects can be substantial, and relapse rates remain high (Yiu et al., 2024)

The vitamin's role in homocysteine metabolism is particularly relevantdeficiency leads to elevated homocysteine levels and methylmalonic acid, which may contribute to neurological dysfunction

PMID 15717864

Similarly, concentrations of DMSO ranging from 0.01-1% were reported to cause hyperactivity in zebrafish larvae, with morphological abnormalities noted only at the 1% exposure group 50