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N-acetyl-cysteine infusion was found to better tolerate the respiratory loading by increasing the time to respiratory arrest

Upon pooled analysis, the ORR and disease control rates (DCR) of Child-Pugh B patients treated with ICIs were 14% (95% confidence interval [CI] 11-17%) and 46% (95%CI 36-56%), with a median OS and median progression-free survival (PFS) of 5.49 (95%CI 3.57-7.42) and 2.68 (95%CI 1.85-3.52) months, respectively

Controls were mainly characterized by a high expression of SOD1 protein, whereas sALS samples were characterized by high Ci for complexes I and IV (a coefficient that represents the control of metabolic fluxes by a given enzyme), and fALS samples were characterized by a high rate of maximal respiration with substrates for complexes I and II and a high level of the complex I NDUFB8 subunit

A3: The procedure is painless, and you may only feel a slight discomfort as the IV drip is administered into your vein

Additional information Liang Tang and Weiwei Wang contributed equally to this work Additional file Additional file 1

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