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PMID: 42 GaoLZhangYHuZChenSWangQZengYet al

Pyroptosis can be identified by a combination of specific markers, which include TLR4, GSDMD, activation and release of pro-inflammatory IL-1 and IL-18, as well as the activation of cysteinyl aspartate specific proteinases, such as caspase-1, caspase-3, caspase-4, caspase-5, and caspase-11 (125)

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doi: 10.1016/j.cell.2024.05.013, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Schauwvlieghe A., Rijnders B

Intervention of lactylation-related enzymes The majority of lactylation is mediated by enzymes, making the targeted intervention of these key regulatory enzymes, particularly the writers, a crucial focus for research into targeted therapy strategies for lactylation