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Nature 174, 2831.10.1038/174028a0 46 GibbsM

Various FDA-approved marketed drugs are shown in Table 5 [127]

These findings are especially relevant since psoriasis is now recognized as a systemic immune-mediated disease rather than a purely cutaneous condition

5,8 Our data demonstrate that of the 5 prosurvival BCL-2 family members, only BCL-2 mRNA levels consistently anti-correlate with the AR-A in all clinical datasets we have interrogated and only BCL-2 is consistently induced by castration (e.g., in 3 of the 4 xenograft AI models) (Fig