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This strengthens the role of lithium in maintaining synaptic function by GSK-3 and IMPA-dependent mechanisms (see Figure 1B)

Articles of experimental studies, clinical observational studies, meta-analyses, and high-quality narrative or systematic reviews were first selected

GemelliIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Universit Cattolica del Sacro Cuore, Rome, Italy

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Within this multifactorial setting, magnesium depletion is unlikely to be a primary cause but may act as a disease modulator that lowers the cellular threshold for dysfunction and amplifies injury