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NAC N acetylcysteine boosts glutathione, the brain's key antioxidant. Meta analyses show it can ease depressive and anxiety symptoms when used as adjunct therapy for OCD or bipolar depression. Typical doses range Frontiers Glutathione and neurodegenerative diseases: immunopharmacological implications Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect PMC Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders Effects of Nacetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis PMC Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice Nature

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