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Transcellular water movements are facilitated by the water channels, aquaporins (AQP) type 9 and 8, located at the basolateral and apical membranes, respectively.46 As expected for a solute exerting osmotic forces at the canalicular level, a linear relationship between bile salt secretion and bile flow has been observed in all vertebrates, including man

Although we have demonstrated target engagement of both compounds, additional experiments could also explore the possibility of off-target effects of both SIH and Lip-1

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The background articles included studies to demonstrate the importance of removing all residual disease (lesions) to improve patients' survival

& Birembaut, P