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In the CNS many of the pathological effects of kynurenine pathway activity may result from a balance between the concentrations of quinolinic acid, an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA) ( In addition, over-activation of NMDA receptors is accompanied by increased microglial proliferation and activation together with cytokine production

This is not a dismissal of the compound

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A good antioxidant should specifically quench free radicals, chelate redox metals, interact with other antioxidants within an antioxidant network, have a positive effect on gene expression, be readily absorbed, have a concentration in tissues and biofluids at a physiologically relevant level, act in both aqueous and/or membrane domains (2)

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Vieth R, Kimball S, Hu A, Walfish PG: Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients