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Iodide is non-reactive, and the reactive I2 species is required for the next step

Another route through which CLOCK and BMAL1 can function is by promoting the transcription of the nuclear receptors REV-ERB [also known as NR1D1 (nuclear receptor subfamily 1 group D member 1)] and ROR, which is one of melatonins target receptors

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J Neurosci 19:5629, PMID: 9880576 Dringen R, Gutterer JM, Gros C, Hirrlinger J (2001) Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

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The study was conducted following Iraqi and international ethical and privacy laws, including the World Medical Associations Declaration of Helsinki, The Belmont Report, the CIOMS Guideline, and the International Conference on Harmonization of Good Clinical Practice