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AS-IV targets the expression of CD36, NOX4, TGF-1 and MAPK and regulates the Wnt/-catenin, mTORC1/p70S6K, pSmad3C/p21, pSmad3L/PAI-1 and PI3K/AKT/mTOR signaling pathways, thereby further inhibiting HMC fibrosis, renal fibrosis complicated by DKD or liver cancer, obstructive nephropathy-related fibrosis and the EMT of RTECs

particularly, there is a reordering of six residues at the C-terminus of the large subunit with suggested role in enzyme catalysis (Lin et al., 2014)

A large number of studies have shown that HS will cause high levels of ROS [9, 60, 61]

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Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression

For example, the mechanosensitive ion channel Piezo1 is markedly upregulated in the colonic mucosa of patients with UC (Zhou et al., 2025a), and its excessive activation exacerbates epithelial injury, in part by promoting ferroptosis (He H