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Its multifactorial pathophysiology, progressive trajectory, and lack of disease-modifying treatments underscore the need for early, multi-targeted, and personalized approaches

Moreover, a notable reduction in levels of C-reactive protein was seen, suggesting a possible role in reducing the hazard of cardiovascular disorders

Proc Natl Acad Sci USA 95(6):29562960 Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation