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Apply the contents of the ampoule in a gel prepared for use in needle-free mesotherapy or virtual mesotherapy, or to enhance the results obtained with electrotherapy techniques such as ultrasound, ionization, diatherapy or other types of medical device used in beauty treatments

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It was not long thereafter that the first reports describing serious complications were published, and for this reason, implants had to be removed, leaving some patients almost blind (Hoguet et al., 2012