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However, issues included the use of toxic cyanide-containing substances, the high cost of resolving agents and catalysts, the challenge of utilizing the other enantiomer from the resolution, numerous reaction steps, low yield, high cost, and high product price

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7.2 Clinical Interactions Affecting Vitamin Levels Hydralazine, Isoniazid Pyridoxine requirements may be increased by concomitant administration of hydralazine or isoniazid

These studies on myocardial injury and the GSH system reveal new roles of these clinical drugs in the treatment and further elaborate their mechanisms, which provide new ideas for their clinical application

2011;43(9):825-827 Dobbins SE