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PML is a ROS sensor activating p53 upon oxidative stress

Karanth School of Health Professions and Human Services, Hofstra University, Hempstead, NY, USA Ibraheem M

To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

Generally, lipid peroxidation can be divided into two types: enzymatic oxidation (with enzymes) and free radical chain reactions (non-enzymatic), through which PUFA can be oxidized and broken down into toxic derivatives such as 4-HNEs and malondialdehyde (MDA) (Feng and Stockwell, 2018)

Recent studies have revealed alteration in the status of post-translational modifications, such as phosphorylation and methylation, in the promoters of the core clock genes in cancerous tissues, leading to the deregulation of clock gene expression 98,99

Ulcerative Colitis and Anemia: What's the Link