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Interestingly, mechanotransduction in aged individuals and those with glaucoma appear to be compromised across all tissues of the eye (cornea, sclera, TM, retina), suggesting broad dysfunctions in the cells ability to generate and process mechanical forces

The phase 2 trial published in the New England Journal of Medicine documented heart rate increases across every dose group

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Based on this stratification framework, a mapping relationship of mechanism targetbiomarkerintervention choice can be established, providing an actionable roadmap for the precision of multi-target combination therapies