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In contrast, the morphology and structure of cells treated with CoNPs and ALA together are similar to those of the control group, showing negligible damage of cells (Fig

L-NAME was used to construct a PE rat model, and the p53 inducer Nutlin-3 and p53 inhibitor MG-132 were used to construct PE rat models of p53 overexpression (p53 +/+) and inhibition (p53 /), after which the general condition of each group of rats was evaluated

Methods Bioinformatics analysis The sequences of the enzymes of the transsulfuration pathway cystathionine beta synthase (CBS) and cystathionine gamma lyase (CGL) of Saccharomyces cerevisiae were collected from NCBI Database