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Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

The tradeoff is that more water means fewer total days per vial (you cannot exceed the 28-day reconstituted shelf life) and a higher volume per injection

Sabeti P, Pourmasumi S, Fagheirelahee N

Today, experts believe that the central workings of B12 in the nervous system are the methylation functions, production of S-adenosylmethionine (SAM) and formation of glutathione