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Disturbances in the endoplasmic reticulum can be triggered by increased oxidative stress, deposition of saturated fatty acids, hypoxia, or other stimuli, which in turn cause the accumulation of unfolded proteins in the endoplasmic reticulum lumen that is filled with proteins, antioxidants, or essential metals

However, FMT's mechanism of action in psychiatric disorders remains uncertain, donor screening and long-term safety require further clarification, and at present, no recommendations can be made for its routine use outside of clinical research

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease

J Thorac Oncol 8(2):222-8, 2013

In this article What is histamine and what does it do

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