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Agents with a well-established use or under investigation for COVID-19 treatment were included in the analysis, namely: bamlanivimab, canakinumab, casirivimab/imdevimab, colchicine, darunavir/cobicistat, dexamethasone, enoxaparin, lopinavir/ritonavir, remdesivir, ruxolitinib, siltuximab, tocilizumab

Many medical experts have warned against that recommendation, citing a lack of evidence

Hepatogastroenterology 41:328332 Nakazawa J, Genka C, Fujishima M (1996) Pathological aspects of active oxygens/free radicals

23 In clinical trials for MS, monoclonal antibodies targeting B cells and T cells, such as the anti-CD52 monoclonal antibody alemtuzumab and the humanized anti-CD20 monoclonal antibody ocrelizumab, have demonstrated promising efficacy, offering hope for MS treatment

The mechanism that was supposed to be responsible for the activation of Nrf2 involves oxidation of cysteine residues of Keap1 under oxidative stress, resulting in the dissociation of the Keap1Nrf2 complex and translocation of Nrf2 to the nucleus, where it forms a dimeric complex with small Maf protein

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