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History Scientific interest in NNMT increased substantially during the early 2000s as researchers discovered its involvement in metabolic regulation, cellular methylation processes, and adipose tissue function

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In preclinical studies published in Endocrinology, researchers found that chronic administration of AOD-9604 reduced body weight and body fat in obese mice while increasing beta-3 adrenergic receptor expression to levels comparable with lean mice

Their fat deposits shrank by 39%

MOTS-c has been shown in preclinical studies to improve insulin sensitivity, increase glucose utilization in skeletal muscle, and protect against age- and diet-related metabolic dysfunction

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