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The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

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Classic coagulation tests like INR and partial thromboplastin time (PTT) are not helpful for assessing anticoagulant activity because results may be normal or abnormal, and prolongation of these clotting times do not reflect the degree of anticoagulant activity present