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Especially the levels of the monoacylglycerol 2-arachidonoylglycerol were significantly lower in the aged xCT / compared to aged xCT +/+ hippocampus (Fig

Under oxidative stress, either Grx or Trx can reduce disulfide bonds through GR or TR (thioredoxin reductase) and NADPH, preventing the accumulation of misfolded proteins [40,41]

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However, we also need to recognise that glutathione exists in two major forms: reduced and oxidised - thus, it is a molecule involved in redox biochemistry = the reason it is such an effective antioxidant