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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation

Rasool A, Manzoor R, Kaleem U, Kaleem I, Bashir S, Farrukh A, Khattak S, Haq A, Afzal R (2023) Oxidative stress and dopaminergic metabolism: a major PD pathogenic mechanism and basis of potential antioxidant therapies

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Plasma and cerebrospinal fluid pharmacokinetics of vodobatinib, a neuroprotective c-Abl tyrosine kinase inhibitor for the treatment of Parkinsons disease

These findings collectively show that astaxanthin, with its high antioxidant characteristics, can be used as an adjuvant treatment in a variety of respiratory disorders, including pneumonia and COVID-19, by lowering oxidative stress and modifying inflammatory responses