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Clinician Perspective The ADA Standards of Care 2024 state directly: "Routine supplementation with antioxidants, such as vitamins E and C and carotene, is not advised because of lack of evidence of efficacy and concern related to long-term safety." [6] Glutathione is not explicitly addressed in this language, but the guidance reflects a broader evidentiary standard the ADA applies to antioxidant supplements in diabetes management

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This activation of the NRF2-ARE pathway positions delphinidin as a potential chemopreventive agent for skin cancer [158]

Species such as Lactobacillus , Bifidobacterium , Bacteroides , and Clostridium generate AhR agonists that can suppress the pro-inflammatory phenotype of glial cells [163, 165]