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Additionally, sirolimus treatment reduced fibrocyte concentration in IPF patients by 35%, showing potential for PI3K/mTOR inhibition in fibrosis management [148] (Table 2)

Flavonoids have also been proven to influence macrophage polarization by regulating metabolic reprogramming

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Examples include cord blood used for hematopoietic disorders, B-cell maturation agents used for large B-cell lymphoma, and autologous cellular products consisting of fibroblasts used for nasolabial fold wrinkles (24)

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In a 16-week randomized, double-blind, placebo-controlled study, NAC (3 g/day) only decreased anxiety symptoms in patients with treatment-resistant OCD