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It typically occurs after the age of 45

Cani PD, Possemiers S, Van de Wiele T, et al

Increasing the ingested dose above 5 g should be avoided since this will alter intestinal motility and water handling through its osmotic effect

Department of Justice, Diversion Control Division IGF-1 LR3: More Affordable but Research-Only IGF-1 LR3 is not FDA-approved for human use , and it is typically labeled for research purposes only. However, its widely available through peptide and research chemical suppliers