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Some cases received immunotherapy early because the presentation appeared autoimmune, only for neurosyphilis to later emerge as the unifying diagnosis and antimicrobial therapy to become decisive ( Discussion Three scenarios: mimic, overlap, and trigger These observations support an infectionautoimmunity interface rather than a strict dichotomy (Table 1)

Faergeman et al., 2020

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Raghu G, Weycker D, Edelsberg J, Bradford WZ, & Oster G

Additionally, hepatocytes harbor robust metabolic systems for converting cholesterol into bile acids or oxysterols, which likely mask the impact of increased cholesterol influx