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Nevertheless, some drawbacks such as derivatization, cumbersome laboratory procedures, time consumption and applicable feasibility in vivo were not conducive to the development of a practical method

10.1248/bpb.b15-00716 38

211,212 Such constructed upconversion NPs/MSNs nanocomposites-based platform offers a wide range of applications of the upconversion NPs in the biomedical field

In one single-center trial of 72 subjects using a controlled-adverse-environment model, the T4 eye drop did not meet its co-primary endpoints (ocular discomfort and inferior corneal staining) at the primary time point, but it did produce statistically significant improvements on several secondary endpoints, including central and superior corneal staining, with no adverse events reported

Insertion of the egtA gene was confirmed via Southern analysis

If reconstitution feels like the weak link in your protocol, it probably is