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For example, leukemia cells treated with a histone deacetylase (HDAC) inhibitor showed an increased expression of the nuclear drug target, topoisomerase II (see Sec

Finally, we describe the limited existing evidence for the use of isatuximab or daratumumab after disease progression on prior anti-CD38 mono- or combination therapy, highlighting the need for additional clinical evaluations to define optimal anti-CD38 antibody therapy selection and sequencing in RRMM