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reported that Asp and Asn in colon cancer cell lines could inhibit their activities by binding to LKB1 (encoding filament, threonine kinase, and direct phosphorylation of protein products to activate AMPK), thus inhibiting AMPK-mediated p53 activation

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Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment

Furthermore, nebulized human platelet-derived exosome products have been shown to reduce smoke-induced emphysema in mice by inhibiting NF-B activation, inflammatory cytokine production and apoptotic protein expression, while promoting an increase in CD4+/forkhead box P3+ regulatory T cells in lung tissue, thereby alleviating oxidative lung injury, inflammation and apoptotic alveolar epithelial cell death (95)