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Nature Biotechnology, 28 (3), 245248

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382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms

Once damaged by oxidative stress, neurons may not be able to repair or replace themselves effectively, leading to long-term functional deficits