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Variable patterns of mRNA transcriptions have also been found which lead to a variable protein phenotype resulting in differences in behaviour and response to drugs and growth factors [71]

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While angiogenesis in the adult brain is classically considered quiescent under physiological conditions, mounting evidence from pathological contextssuch as stroke, trauma, glioma, and multiple sclerosisdemonstrates that angiogenic reactivation can occur in response to stress or injury (Thomsen et al