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This evolution is driven by selective pressure from antibiotic use, with factors such as decades of overuse, incorrect dosing, and the widespread use of antimicrobials in livestock, contributing to the selection of resistant strains

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This may be because the self-assembled peptides usually have better stability after forming nanostructures than their corresponding small molecules, and the core assembly sequence of NSBSO was composed of two d-phenylalanines, which can better resist the degradation of enzymes than l-counterparts

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