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Note: Limited by current skills and knowledge, it is impossible to perform all possible cross-reactivity detection tests between GPX4 and all analogs, therefore, cross reactivity may still exist

Under heat stress (39 C), spermatozoa exhibit mitochondrial dysfunction characterized by diminished membrane potential, impaired ATP synthesis, and a marked reduction in the activities of respiratory chain complexes I, III, IV, and V ( Figure 3b ) ( Figure 3b ) ( 4.3 Restoration of autophagic flux and apoptosis inhibition Autophagy is a highly conserved, lysosome-dependent catabolic process essential for the maintenance of cellular homeostasis