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Apr 14 2023 Soto et al., Pharmaceuticals, doi:10.3390/ph16040591 N-Acetyl Cysteine Restores the Diminished Activity of the Antioxidant Enzymatic System Caused by SARS-CoV-2 Infection: Preliminary Findings Prospective analysis of 16 COVID-19 patients treated with NAC and 20 healthy controls, showing that NAC may help restore diminished activity of the antioxidant enzymatic system in patients with COVID-19

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doi: 10.1016/0014-5793(94)00429-3

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Binding of PARP to strand breaks promotes poly(ADP) ribosylation of nuclear accessory proteins, forming negatively charged branch polymers that recruit enzymes that accomplish repair of the gap