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However, this therapeutic effect is reversed by administration of the PI3K inhibitor LY294002, suggesting that sipeimine combined with rosavin regulates ferroptosis via the PI3K/AKT/Nrf2 pathway, addressing PM 2.5 -induced damage to the lungs [103]

The few case reports presented in this review should not be considered as a useful index of the frequency of occurrence of serious grapefruitdrug interactions in general practice, as these are likely underreported