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Neurorehabil Neural Repair 18(4):18798 Cantor JB et al (2012) Insomnia, fatigue, and sleepiness in the first 2 years after traumatic brain injury: an NIDRR TBI model system module study

Nevertheless, a subset of patients continues to face therapeutic challenges associated with primary/secondary treatment failure, adverse reactions, and disease heterogeneity, which has driven the development of emerging therapies based on pathological mechanisms

Notably, the mitochondrial uncoupling agent FCCP, which diminishes mitochondrial membrane potential and ATP production, did not influence cuproptosis, implying that ATP synthesis is dispensable for this process

Numerous studies indicate that the expression of SLC7A11, GSH, and GPX4 decreases following CIRI (Guan et al., 2021

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This can result from several factors, including hormonal changes, sun exposure, smoking, and even the use of certain cosmetics