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The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM 5-TR) describes OUD as a pattern of opioid use leading to problems or distress, where at least two of the following occurring within a 12-month period: Taking larger amounts or taking drugs over a longer period than intended

Recent developments have begun to shed light on combination treatments with other therapies, such as chemotherapy, radiation therapy, immunotherapy, or targeted therapy (Secondini et al., 2017