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Among the literature surveyed, protein samples were prepared through MilliporeSigma BugBuster [89, 90] or AVESTIN EmulsiFlex C-3 cell disruptor [91, 92], and were concentrated through MilliporeSigma Amicon Ultra concentrators [93, 94], Thermo Fisher Sartorius spin columns [95] or through Vivaspin concentrators [96-98]

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Importantly, such volumetric reductions are not merely artifacts of neurodegeneration

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