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Injectable GHK-Cu is delivered systemically rather than absorbed through the skin, which produces different (and generally more pronounced) systemic effects than topical copper peptide cosmetics

The study was supported partly by a research agreement with AmorePacific Corporation (a major Korean cosmetics company)

A 2022 randomized controlled trial (RCT) in Dermatologic Therapy (n=71, 12 weeks) found 1% GHK-Cu cream was associated with a reduction in wrinkles by 55.7% (vs

This variability likely reflects differences in underlying pigmentation mechanisms, treatment concentrations, vehicle formulations, and patient populations

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This explains why 2-3 weekly injections produce cumulative collagen synthesis and sustained anti-aging benefits despite rapid peptide elimination