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Among the 1,051 Pc binding circadian rhythm-related genes in this cluster of neurons (Fig 4), the presence of key clock regulatory genes such as per (Yang & Sehgal, 2001

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This upregulation is associated with chromatin remodeling, which is characterized by di- and tri-methylation of histone H3K4 and preferential binding of c-Rel at the p19 promoter, contributing to age-related inflammatory responses