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That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it

Low reduced and oxidized glutathione ratios (GSH/GSSG) are often found in dogs with various hepatopathies (i.e., necroinflammatory liver disorders, extrahepatic bile duct obstruction, copper toxicosis, chronic extrahepatic cholestasis, and chronic hepatitis), along with decreased values of antioxidant enzymes and total antioxidant capacity indexes [90,91,92,102,104]

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For example, liver dysfunction or failure impacts the ability of the liver to filter toxic substances, such as waste products from digestion, which can result in hepatic encephalopathy

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Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS