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Studies have shown that the use of ferrostatin-1 (Fer-1, a ferroptosis inhibitor) can increase T-cell activity, and its combination with anti-PD1/L1 immunotherapy leads to the enrichment of CD8 + T cells in tissues, significantly increasing the immune infiltration of CD8 + T cells ( + T-cell activity ( + T cells and that HFEs can influence their activity in a sex-specific manner

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Furthermore, this review identifies potential therapeutic targets by elucidating the mechanisms of inflammasome activation and their downstream effects

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