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Melatonin, a neuroendocrine hormone, is a potent signaling molecule that coordinates reproductive events by controlling the release of reproductive hormones and interacting with other systems, such as the immune system, to optimize reproductive functions (7)

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Mechanical ventilation, whilst necessary in critical care, increases the risks of lung trauma, ventilator associated pneumonia, and physical/respiratory deconditioning leading to adverse clinical outcomes [71]

LPS impairs steroidogenesis and ROS metabolism and induces PPAR transcriptional activity to disturb estrogen/androgen receptor expression in testicular cells