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This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development ( - expression and promoting lipid peroxidation, ultimately triggering ferroptosis ( Notably, androgen excess, a hallmark of PCOS, may also contribute to ferroptosis

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Erastin can elevate the level of HSP90, a molecular chaperone, which partially accentuates ferroptosis by amplifying GPX4 autophagic degeneration[169]

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The pH of supplemented water is as follows: 6.88, 20 mM BSO

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