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Although synaptic Glu-Gln cycling and neuronal activity are likely diminished in GS cKO mice, the astrocytic build-up of Glu and ammonium may lead to a metabolic burden and oxidative/nitrosative stress within astrocytes, a situation attributed to GS deficiency [23]

Unlike some other GH secretagogues, ipamorelin shows minimal activity on ACTH, cortisol, prolactin, or other pituitary hormones

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