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These opioid-like peptides have been detected in various biofluids, such as serum, urine, and cerebrospinal fluid

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doi:10.1177/030006059001800304

Dysesthesia The TRIUMPH-4 trial data revealed a notable safety signal: dysesthesia (abnormal sensations like tingling, burning, or numbness) was reported in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose of retatrutide