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Aberrant methylation of the cyclooxygenase 2 CpG island in colorectal tumors Cancer Res 2000 60 : 40444048 Noguchi Y, Makino T, Yoshikawa T, Nomura K, Fukuzawa K, Matsumoto A, Yamada T

J Biol Chem 278:4719047198 Jimenez A, Hernandez JA, del Rio LA, Sevilla F (1997) Evidence for the presence of the ascorbate-glutathione cycle in mitochondria and peroxisomes of pea leaves

An attractive approach to tackle this issue may be the utilization of unnatural derivatives

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Maternal witness defeat stress and THC exposure Pregnant dams received daily subcutaneous injections of THC (2 mg/kg, 2 ml/kg) or vehicle from gestational day 3 (GD3) until birth, corresponding to early-mid gestational periods of cortical and limbic development

This allows cancer cells to neutralize ROS generated by rapid cell division and metabolic activity, contributing to chemoresistance in PDAC [66,67]