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Degarelix is soluble in aqueous solvents and given subcutaneously in forming gels at high concentrations and from which it can diffuse in a way similar to the release from depot formulations of peptide from microcapsules 25

Age and activity level play a role too

10.1016/j.phymed.2021.153637 242 TohdaC.MatsuiM.InadaY.YangX.KuboyamaT.KimbaraY.et al (2020)

Individualized therapeutic approaches must incorporate comprehensive assessment of residual renal function, concurrent medication regimens, and patient-specific risk factors including age, comorbidity burden, and genetic polymorphisms affecting drug metabolism

Aside from internal genetic properties, trans-acting factors have also been postulated to affect the stability of FMR1 during mitosis and meiosis (Mornet et al., 1996

Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells